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KMID : 1038620210390030231
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Radiation Oncology Journal
2021 Volume.39 No. 3 p.231 ~ p.238
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Comparison of radical prostatectomy and external beam radiotherapy in high-risk prostate cancer
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Chun Seok-Joo
Kim Jin-Ho
Ku Ja-Hyeon
Kwak Cheol
Lee Eun-Sik
Kim Su-Zy
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Abstract
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Purpose: We evaluated clinical outcomes of high-risk prostate cancer patients receiving external beam radiotherapy (EBRT) or radical prostatectomy (RP).
Materials and Methods: Patients were classified as high-risk prostate cancer and received definitive treatment between 2005 and 2015. Patients with previous pelvic radiotherapy, positive lymph node or distant metastasis were excluded. The primary outcomes were prostate cancer-specific survival (PCSS) and distant metastasis-free survival (DMFS).
Results: Of 583 patients met the inclusion criteria (77 EBRT and 506 RP), the estimated 10-year PCSS was 97.0% in the RP and 95.9% in the EBRT (p = 0.770). No significant difference was seen in the DMFS (p = 0.540), whereas there was a trend in favor of RP over EBRT in overall survival (OS) (p = 0.068). Propensity score matching analysis with confounding variables was done, with 183 patients (66 EBRT and 117 RP) were included. No significant difference in DMFS, PCSS or OS was found.
Conclusion: Our data demonstrated similar oncologic PCSS, OS, and DMFS outcomes between EBRT and RP patients.
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KEYWORD
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Radiotherapy, Prostatectomy, Prostatic neoplasms
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